PyQt is a popular Python binding for the Qt application framework, which is used to create desktop and mobile applications.
wxPython is another popular Python GUI framework that is based on the wxWidgets C++ toolkit.
Tkinter is the standard GUI library for Python and is included with most Python installations.
PyGTK is a set of Python bindings for the GTK+ graphical user interface library.
PySide is another Python binding for the Qt application framework, similar to PyQt.
Kivy is a Python GUI framework that is designed for multi-touch applications and runs on Android, iOS, Linux, macOS, and Windows.
PyGUI is a simple and lightweight Python GUI framework that is designed to be easy to use and fast.
PySDL2 is a Python binding for the SDL2 multimedia library, which is used to create games and other multimedia applications.